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Agonist/Antagonist Opioid Analgesics. When a client has Earlier been given or is currently undergoing a training course of therapy with a pure opioid agonist analgesic like Dilaudid, agonist/antagonist analgesics like pentazocine, nalbuphine, butorphanol, and buprenorphine, needs to be used with caution.Hydromorphone injection is used To alleviat